Entissar Mansour Abdul Rasool; Man Samir Balola
Volume 25, Issue 1 , March 2025, , Pages 193-202
Abstract
Boswellia serrata (B.serrata) is commonly defined as a resin, widely used because of the healing properties of inflammations and other diseases due to its powerful antioxidant action. This study investigates the effect of B.serrata on reproductive system and metabolic hormones in adult male rats. Four ...
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Boswellia serrata (B.serrata) is commonly defined as a resin, widely used because of the healing properties of inflammations and other diseases due to its powerful antioxidant action. This study investigates the effect of B.serrata on reproductive system and metabolic hormones in adult male rats. Four groups of adult male rats (10 rats each) were subjected to the trail. Group 1 (control ) rats were fed on normal diet (ND), group (2) rats were fed on high fat diet (HFD), group (3) rats were fed ND and aqueous B.serrata extract (1000 mg/kg body weight/day), and group (4) rats fed on HFD and aqueous B.serrata extract at the same dose respectively for the duration of 60 days. The results indicated that feeding on HFD resulted in hyperlipidemia, significant (p≤0.05) reduced level of testosterone, insulin, TSH and the antioxidant enzymes (GSH, SOD,CAT), significant (p≤0.05) elevated levels of lipid profile, oxidative markers (MDA) and cytokines (TNF-α, IL-6 and IL-1β) concentration. Negative effects on spermatogenesis was also observed, confirmed by significant (p≤0.05) decrease in sperm concentration and sperm motility in addition to significant (p≤0.05) increase in the percentage of dead and abnormal sperm. Daily aqueous B.serrata extract administration for 60 days managed to adjust all the metabolic disorders and enhanced rats fertility. The study concluded that the administration of B.serrata extract improves the adverse effects of high fat diet by acting as antidyslipidemic, anti-inflammatory and antioxidant agent. B. serrata extract is also able to correct the disrupted metabolic pathways, with positive effect on male fertility.
Mina H. Mahdi; Yasmine I. Khalil
Volume 22, Issue 2 , June 2022, , Pages 36-43
Abstract
The study aims to detect the effect of adding of Bacillus licheniformis bacteria (1 × 108 cells/day/animal) to reduce the negative effect of cholesterol added to the food ration by 2% on body weights and the effect on some parameters, blood images and lipid profiles in male laboratory rats after a period ...
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The study aims to detect the effect of adding of Bacillus licheniformis bacteria (1 × 108 cells/day/animal) to reduce the negative effect of cholesterol added to the food ration by 2% on body weights and the effect on some parameters, blood images and lipid profiles in male laboratory rats after a period of 28 days. In this study, 15 adult male Albino Sprague- Dawleyweanling rats of 8-9 weeks of age and average weight of 142 g are used. The animals are randomly distributed into 3 groups with each group consisting of 5 animals. The results show that the addition of cholesterol causes a significant increase at (P<0.05) in body weight, as the weight gain is 43.18 g compared with 19.13 g in the control group. The results also show a decrease in total number of red blood cells, hemoglobin levels, HCT and a significant increase in the number of white blood cells and platelets for groups of rats feeding cholesterol at (6.12 , 10.44 , 35.32 , 11.94 , 850.60) compared with the control group (7.09 , 12.30 , 38.54 , 9.22 , 597.40) respectively. The results also show an increase in the level of cholesterol, LDL and triglycerides, and a significant decrease in the level of HDL compared to the control group .The addition of Bacillus licheniformis with cholesterol has a significant effect in reducing the negative effect of cholesterol on all the above-measured parameters.
