Document Type : Articles
Authors
1 Haret Hreik- Dakkash street- Bdeir Building- 2nd floor
2 College of Education for Pure Sciences, University of Tikrit, Tikrit/Iraq.
3 College of Education for Pure Sciences, University of Tikrit, Tikrit/Iraq
Abstract
This sub-chronic toxicological study explored the potential adverse effects of repaglinide, an antidiabetic medication, on liver and lung function in rats following 30 days of repeated oral exposure. Male Wistar rats were assigned to three groups: a control group, a group receiving repaglinide at the therapeutic dose of 0.7 mg/kg, and a group receiving double the therapeutic dose of 1.4 1.4mg/kg. Blood glucose levels, liver enzymes, and various hematological parameters were measured, and histological examinations of liver and lung tissues were conducted. The study showed that both repaglinide-treated groups had higher levels of liver enzymes (p < 0.05) and changes in hematological parameters, such as higher erythrocytes, hemoglobin, hematocrit, and white blood cells, and lower levels of platelets, compared to the control group. In the lungs of the rats that were treated, histopathological analysis showed that inflammatory cells had moved in, the central vein was swollen, and the walls of the air sacs were getting thicker. These results suggest that repaglinide treatment, especially at higher doses, may lead to adverse effects on liver and lung function in rats, highlighting the need for careful monitoring during its therapeutic use.
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